DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2Article Published on 2022-10-062022-11-15 Journal: Nature Communications [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] administration animal challenge model antibodies antibody cocktail Antigen antiviral potency binding cryo-EM demonstrated Efficacy effort exhibit forms functional High-resolution in vivo Interaction lineages mAb monoclonal antibody monoclonal antibody therapy omicron performed populations promote Prophylactic Prophylaxis Protective Protein SARS-CoV-2 serum antibody specificity Strategy Support trimeric [DOI] 10.1038/s41467-022-33309-6 PMC 바로가기
Immunological study of COVID-19 vaccine candidate based on recombinant spike trimer protein from different SARS-CoV-2 variants of concernArticle Published on 2022-09-292022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] addition AstraZeneca Beta booster booster dose CD4 CD4+ CD8+ central memory ChAdOx1 Concentration COVID-19 COVID-19 vaccine Delta evaluated follicular highest homologous IFN-gamma IgG IgG antibody IgG isotype IL-17 Immune escape immunogenic immunogenicity induce memory mice mice immunization neutralizing antibody Neutralizing antibody titer new SARS-CoV-2 performed Population populations Protein S protein SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 variant SARS-CoV-2 variants significantly higher spike trimer spike trimeric protein T cells tested trimeric Trimeric spike protein Vaccine vaccine candidate vaccine candidate. Vaccines variant variants viral variant virus viruses VoC Wuhan [DOI] 10.3389/fimmu.2022.1020159 PMC 바로가기
Intranasal immunization with recombinant Vaccinia virus encoding trimeric SARS-CoV-2 spike receptor-binding domain induces neutralizing antibodyArticle Published on 2022-09-222022-11-15 Journal: Vaccine [Category] SARS, 진단, 치료기술, [키워드] BALB/c mice Bronchoalveolar lavage fluid cellular immune responses COVID-19 detectable dissemination domain Effects elicited evaluated exhibited expressing humoral IgA IgG immune response immunization immunized induce Infection intranasal Lymphocytes mice mucosal mucosal immune nasal washe neutralization neutralization activities Neutralizing Neutralizing antibodies neutralizing antibody RBD respiratory response robust SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein secretory IgA sera systemic immune response transmission of SARS-CoV-2 trimeric trimeric RBD Vaccine vaccinia vaccinia virus. virus [DOI] 10.1016/j.vaccine.2022.08.054 PMC 바로가기
A self-assembled trimeric protein vaccine induces protective immunity against Omicron variantArticle Published on 2022-09-172022-11-15 Journal: Nature Communications [Category] SARS, 변종, 진단, [키워드] addition animal models B.1.1.529 Breakthrough infection circulating clinical trials Complete Delta delta variant dose elicited humoral immune response Immune escape immune response in vivo induce L452R Live virus mice mRNA vaccines neutralizing antibody non-human primates omicron predominant prime-boost regimen protective immunity Protein RBD resulting SARS-CoV-2 SARS-CoV-2 S2 SARS-CoV-2 vaccine SARS-CoV-2 variant sequence subunit surpassed sustained T cell T478K Transmissibility trimer trimeric vaccinated individuals vaccination Vaccine vaccine candidate variant variants [DOI] 10.1038/s41467-022-33209-9 PMC 바로가기
Isolation of an escape-resistant SARS-CoV-2 neutralizing nanobody from a novel synthetic nanobody libraryArticle Published on 2022-09-162022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] accelerated affinity Affinity maturation amplification antibodies antibody binding CDR Cdr1 CDR2 COVID-19 COVID-19 pandemic Electroporation expand fusion protein humanized IC50 Isolation moderate Mutagenesis Mutation nanobody neutralization Neutralizing omicron performed plaque reduction neutralization PRNT randomization RBD Reactions Receptor binding domain robust SARS-CoV-2 SARS-CoV-2 neutralization SARS-CoV-2 variant SARS-CoV-2 variants subsequent synthetic library. therapeutic potential trimeric Vaccine development variant VHH [DOI] 10.3389/fimmu.2022.965446 PMC 바로가기
Protein Scaffold-Based Multimerization of Soluble ACE2 Efficiently Blocks SARS-CoV-2 Infection In Vitro and In VivoArticle Published on 2022-09-012022-11-15 Journal: Advanced Science [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 affected approach block comparable decoy receptors dimeric effective Efficiency escape mutations fused greater in vivo inhibit SARS-CoV-2 isolates monoclonal antibodies monomeric MoonTag multimerization Mutation mutations neutralization neutralized Neutralizing offer provide sACE2 sACE2. SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SunTag Therapeutic treatment Treatment trimeric unlikely variants of concern [DOI] 10.1002/advs.202201294 PMC 바로가기
A mosaic-type trimeric RBD-based COVID-19 vaccine candidate induces potent neutralization against Omicron and other SARS-CoV-2 variantsArticle Published on 2022-08-252022-11-15 Journal: eLife [Category] SARS, 변종, 진단, [키워드] antibody BBIBP-CorV booster Breakthrough infection broad-spectrum circulating variants combating COVID-19 COVID-19 vaccine cross-neutralizing antibody develop effective elicited homologous immunogenic immunology inactivated indicate induce Infectious disease Inflammation Microbiology Mutation neutralization omicron Omicron variant pandemic Population RBD SARS-CoV-2 SARS-CoV-2 variant spike receptor-binding domain Test trimeric Vaccine vaccine candidate Vaccines variants viruses viruses. with COVID-19 [DOI] 10.7554/eLife.78633 PMC 바로가기
A platform technology for generating subunit vaccines against diverse viral pathogensArticle Published on 2022-08-182022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] acting affinity tag animal model Antigen binding can be used Clamp conformation COVID-19 pandemic Ebola virus elicit epitope fusion fusion protein glycoprotein immune response immunologically Infectious disease MERS-CoV Microscopy middle molecular monoclonal antibody mRNA neutralising Neutralising Antibodies Nipah virus offer platform precursor prefusion purification reagent remained respiratory syndrome coronavirus shown size exclusion chromatography stability stimulated Streamline subunit Subunit vaccine subunit vaccines tested trimeric Vaccine vaccine candidate vaccine platform Viral antigen viral challenge viral pathogen viral. virus virus [DOI] 10.3389/fimmu.2022.963023 PMC 바로가기
A circular mRNA vaccine prototype producing VFLIP-X spike confers a broad neutralization of SARS-CoV-2 variants by mouse seraVFLIP-X 스파이크를 생성하는 원형 mRNA 백신 프로토타입은 마우스 혈청에 의한 SARS-CoV-2 변이체의 광범위한 중화를 제공합니다Article Published on 2022-08-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] addition Amino acid amino acid sequence amino acids Antibody titers B.1.1.529 B.1.617.2 balance BNT162b2 boost cellular immune responses cleavage site COVID-19 vaccine Critical D614G detectable Disulfide disulfide bond E484K Evolution of SARS-CoV-2 FIVE flexible glycosylation greater humoral Humoral and cellular immune responses immune responses immunization immunized induce K417N L452R linear linker mice mRNA mRNA vaccine mRNA vaccines mRNA-1273 N501Y neutralization Neutralizing activity Neutralizing antibody response Neutralizing antibody titer neutralizing antibody titers offer pre-fusion producing proline proline substitutions prolines reduced response S-2P SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus sequence sera shown spike Spike protein spike trimer stability suggested T478K the spike protein transcript trimer trimeric Vaccine vaccine. Vaccines variant variants variants of concern variants of interest VFLIP virus VOCs VOIs wildtype [DOI] 10.1016/j.antiviral.2022.105370 PMC 바로가기 [Article Type] Article
Mucosal administration of a live attenuated recombinant COVID-19 vaccine protects nonhuman primates from SARS-CoV-2 Research Published on 2022-07-292022-10-05 Journal: NPJ Vaccines [Category] 비임상, 임상, 치료기술, 치료법, [키워드] acute respiratory syndrome administration African green monkey AGM AGMs Beta chimeric clinical trial coronavirus COVID-19 COVID-19 vaccine cross-neutralization Delta elicited exhibited expressing global pandemic host cells immunogenic immunoglobulin A intranasal Live attenuated vaccine mucosal neutralizing antibody Phase 1 PROTECT recombinant COVID-19 vaccine reducing respiratory syncytial virus RNA virus SARS-CoV-2 SARS-CoV-2 spike serum Surface glycoprotein trimeric viral envelope protein virus variant [DOI] 10.1038/s41541-022-00509-6 [Article Type] Research